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Clinical reviews
ABSOLUTE NOREPINEPHRINE DOSING FOR BLOOD PRESSURE RESPONSE INDEX CALCULATION: A HYPOTHESIS-GENERATING FRAMEWORK FOR FUTURE VALIDATION
Sistema Nacional de Investigadoras e Investigadores, Instituto Mexicano del Seguro Social
PDF3 pages764 KB
The paper discusses the methodological challenges associated with weight-based norepinephrine dosing, particularly in obese patients, and introduces the concept of the modified Blood Pressure Response Index (mBPRI). It highlights the potential advantages of using absolute norepinephrine dosing for a more accurate representation of vasopressor exposure and its implications for assessing hemodynamic responses in septic shock. The authors suggest that mBPRI may provide prognostic information and outline hypothetical patterns of mBPRI evolution during vasopressor therapy for future validation.
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