ANTIMICROBIAL DOSING IN PATIENTS WITH RENAL DYSFUNCTION

Hospital

Many antimicrobials used in critically ill patients are predominantly eliminated by the kidneys, making dosing optimization crucial. This document highlights the risks of subtherapeutic or toxic drug exposures when applying dosing recommendations from noncritically ill populations to critically ill patients. It emphasizes the use of dosing nomograms and model-informed precision dosing software as effective strategies for improving antimicrobial target attainment in resource-limited settings. The review also discusses emerging technologies for real-time monitoring of antimicrobial concentrations.