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Clinical reviews
ANTISEIZURE MEDICATION DOSING AND MONITORING IN THE INTENSIVE CARE UNIT: A PRACTICAL NARRATIVE REVIEW
Andrew J. Webb, Brooke Barlow, Stephanie L. Seto, Carolina B. Maciel, Joanna Brennan, Aaron M. Cook
PDF202616 pages1.6 MB
Antiseizure medications (ASMs) are frequently utilized in the ICU, where their pharmacokinetics can differ significantly from those observed in healthy individuals. Factors such as organ dysfunction, polypharmacy, and the use of exogenous devices can impact dosing and monitoring. This review compiles data on 15 ASMs, detailing their dosing considerations, therapeutic drug monitoring, and the effects of various treatments like renal replacement therapy and ECMO on ASM exposure. Critical care clinicians are encouraged to integrate these insights into their practice for improved patient outcomes.
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