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Dr Palanyol Nyeko James
The document outlines the progression of chronic liver disease to cirrhosis, describing hepatic fibrosis, portal hypertension, and the spectrum of clinical complications such as varices, ascites, and SBP. It reviews liver function tests, imaging findings, and the platelet count/spleen diameter ratio as non‑invasive predictors of variceal risk. Management recommendations follow current guidelines, including primary and secondary prophylaxis with non‑selective beta‑blockers, endoscopic band ligation, and TIPS, as well as antibiotic prophylaxis for SBP. Global epidemiology and burden of cirrhosis, especially in sub‑Saharan Africa, are highlighted.
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