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Clinical reviews
EFFECT OF STRESS ULCER PROPHYLAXIS WITH PROTON PUMP INHIBITORS VS HISTAMINE-2 RECEPTOR BLOCKERS ON IN-HOSPITAL MORTALITY AMONG ICU PATIENTS RECEIVING INVASIVE MECHANICAL VENTILATION
The PEPTIC Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group, Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group
PDF201911 pages443 KB
The PEPTIC Randomized Clinical Trial was conducted across 50 ICUs in five countries, focusing on patients who required invasive mechanical ventilation within 24 hours of ICU admission. The trial aimed to determine the comparative effectiveness of PPIs versus H2RBs on mortality outcomes. The findings suggest that the choice of stress ulcer prophylaxis may influence in-hospital mortality rates, particularly in patients with varying illness severity.
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