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Clinical reviews
HEPARIN-INDUCED THROMBOCYTOPAENIA
Federal University of Rio de Janeiro, Seha Kidney Care, Imperial College Healthcare NHS Trust
PDF6 pages4.6 MB
HIT is characterized by the formation of IgG antibodies against complexes of platelet factor 4 and heparin, leading to platelet activation and subsequent thrombocytopaenia. The document outlines the incidence of HIT, which is approximately 0.2% among patients exposed to heparin, and emphasizes the importance of clinical suspicion and testing for diagnosis. Management strategies include the cessation of heparin and the initiation of alternative anticoagulants based on the 4Ts scoring system. The document also highlights the need for multidisciplinary collaboration in the management of HIT.
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