INFECTIOUS DISEASES SOCIETY OF AMERICA 2026 GUIDANCE ON THE TREATMENT OF ANTIMICROBIAL-RESISTANT GRAM-NEGATIVE INFECTIONS

University of Pennsylvania Perelman School of Medicine; Northeast Ohio Health Care System; University of Maryland; Dartmouth Hitchcock Medical Center; Weill Cornell Medicine; University of Virginia

The Infectious Diseases Society of America (IDSA) aims to provide timely, evidence-informed guidance on managing antimicrobial-resistant (AMR) infections. This updated guidance document replaces earlier versions and focuses on treatment strategies for infections caused by extended-spectrum β-lactamase–producing Enterobacterales, carbapenem-resistant Enterobacterales, and other difficult-to-treat Gram-negative pathogens. A panel of infectious diseases specialists convened to address critical questions regarding the management of these infections.