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Dr Akugizibwe Charles; Dr JPM Masaba
The presentation introduces metabolic liver disorders, focusing on Wilson's disease and its genetic basis. It then reviews primary biliary cholangitis, highlighting serologic markers, imaging, and therapeutic options. The lecture also details primary sclerosing cholangitis, its association with ulcerative colitis, and current hypotheses on its immune-mediated pathogenesis. Diagnostic algorithms and treatment strategies, including ursodeoxycholic acid and newer agents, are discussed. The material concludes with prognostic considerations and references for further reading.
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