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Clinical reviews
MYOSITIS NON-INFLAMMATORY MECHANISMS: AN UP-DATED REVIEW
Emilia Manole, Alexandra E. Bastian, Niculina Butoianu, Hans H. Goebel
PDF201713 pages1.2 MB
The article provides an updated perspective on myositis, focusing on mechanisms that do not involve inflammation. It emphasizes the interplay between endoplasmic reticulum stress, reactive oxygen species, and myokine production, suggesting that these factors may lead to muscle damage independent of immune cell infiltration. The authors propose that understanding these mechanisms could shift the current paradigm regarding the pathology of idiopathic inflammatory myopathies.
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