SICKLE CELL DISEASE

Jin Han, Santosh L. Saraf

Sickle cell disease (SCD) is a group of inherited disorders characterized by the production of abnormal hemoglobin, leading to various clinical manifestations. The chapter outlines the genetic basis of sickle cell syndromes, including sickle cell trait and different forms of sickle cell disease. It emphasizes the importance of early diagnosis through neonatal screening and details the clinical features, complications, and management options available for patients with SCD. Therapeutic strategies, including the use of hydroxyurea and chronic blood transfusions, are also discussed.