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Wolfson Institute of Population Health, Queen Mary University of London; Whittington Health NHS Trust; Homerton University Hospitals NHS Trust
Unexplained infertility accounts for up to 30% of infertility cases, with various potential causes including reduced oocyte quality and low semen quality. The document reviews diagnostic investigations and predictive models that can guide management options such as expectant management, intrauterine insemination (IUI), and in vitro fertilization (IVF). Current guidelines from NICE and ESHRE are also discussed, emphasizing the importance of evidence-based treatment approaches for couples facing unexplained infertility.
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