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Guidelines & protocols
ACG Clinical Guideline Diagnosis and Management ofAdenomatous Colorectal
Gautam Mankaney, MD; Gregory E. Idos, MD; Elena M. Stoffel, MD, MPH; Jennifer M. Weiss, MD; Shailja Shah, MD, MPH; Emad Qayed, MD, MPH, FACG; Mary Pat Harnegie, MLIS; Carol A. Burke, MD, MACG
PDF35 pages2.9 MB
Hereditary adenomatous colorectal polyposis syndromes, including familial adenomatous polyposis (FAP) and MUTYH‑associated polyposis (MAP), confer high lifetime risk of gastrointestinal cancers. The guideline provides recommendations for identifying at‑risk individuals through personal and family history and germline testing, and for surveillance strategies such as regular ileoscopy and endoscopic removal of polyps. It details surgical options (IPAA, IRA, colectomy) and intervals for endoscopic follow‑up based on polyp burden and histology. Chemoprevention strategies, including celecoxib, are discussed with strength of recommendation and evidence certainty. The document follows the GRADE framework to support clinical decision‑making.
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