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Clinical reviews
ANTAGONIZING THE LEPTIN RECEPTOR IN OBESITY
Clifford J. Rosen, M.D.
PDF20233 pages1.6 MB
Childhood obesity is a complex clinical issue often linked to genetic factors. The document reviews the role of leptin, a hormone involved in regulating energy balance, and discusses how resistance to leptin can complicate treatment. Recent research is presented, detailing cases of children with genetic variants in the leptin gene that hinder effective treatment with metreleptin, a synthetic form of leptin. The findings suggest new avenues for therapeutic strategies in managing obesity.
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