β‑BLOCKER AND CLINICAL OUTCOMES IN PATIENTS AFTER MYOCARDIAL INFARCTION: A SYSTEMATIC REVIEW AND META‑ANALYSIS

Wenxing Yang, Xuehong Sun, Yushu Zhang, Zhi Lu, Zhilong Shu, Kui Zhang

The research investigates the conflicting findings regarding beta-blocker therapy following acute myocardial infarction (AMI) as highlighted in various large-scale observational studies. By conducting a systematic review and meta-analysis, the authors aimed to quantify the long-term effects of beta-blockers across diverse AMI populations. The analysis included a comprehensive search of multiple databases for relevant studies published from 2000 to 2025, focusing on clinical outcomes such as mortality and major adverse cardiac events. The findings suggest that beta-blockers may reduce all-cause and cardiac mortality in post-AMI patients, although they do not significantly affect major adverse cardiac events.