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Clinical reviews
CLINICAL IMPACT OF ADJUSTED VALPROIC ACID LEVEL IN PATIENTS WITH HYPOALBUMINEMIA
American College of Clinical Pharmacology
PDF202611 pages1.0 MB
Valproic acid (VPA) is highly protein-bound, affecting its free fraction and clearance in patients with low albumin levels. This retrospective cohort study involved adult patients with seizures or epilepsy, comparing adjusted and total VPA levels to assess their correlation with safety and effectiveness outcomes. The study highlights the limited data available on VPA use in hypoalbuminemic patients and aims to provide insights into its clinical implications.
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