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Clinical notes
PHARMACOLOGICAL CONCEPTS 2 (2)
Dr Kaduyu Dennis
PPTX19 pages1.3 MB
The document delves into the fundamental principles of pharmacology, with a primary focus on antimicrobial resistance (AMR). It explains how microorganisms develop resistance through mechanisms like decreased drug concentration, enzymatic inactivation, altered target sites, and bypass pathways. The text also details the Post-Antibiotic Effect (PAE) and differentiates between time-dependent and concentration-dependent bacterial killing, providing examples and dosing strategies for each. Finally, it introduces the concept of antibiograms and the World Health Organization's AWaRe classification system for promoting antimicrobial stewardship.
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