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Dominique Suzanne Genest, Christopher J. Patriquin, Christoph Licht, Rohan John, Heather N. Reich
Thrombotic microangiopathy (TMA) is a pathological lesion characterized by microangiopathic hemolytic anemia, thrombocytopenia, and ischemic end-organ injury. Renal-limited forms of TMA can be diagnostically challenging, often delaying targeted therapy. This review highlights advances in understanding the pathophysiology of primary TMA entities and the development of novel diagnostic tools and therapies. It emphasizes the importance of prompt investigation and treatment to reduce morbidity and mortality associated with TMA.
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