Please wait while we open this resource.
K
Clinical reviews
VEXAS SYNDROME IN MYELODYSPLASTIC SYNDROME WITH AUTOIMMUNE DISORDER
Huijun Huang, Wenjun Zhang, Wenyu Cai, Jinqin Liu, Huijun Wang, Tiejun Qin, Zefeng Xu, Bing Li, Shiqiang Qu, Lijuan Pan, Gang Huang, Robert Peter Gale, Zhijian Xiao
PDF5 pages771 KB
VEXAS syndrome is characterized by vacuoles in myeloid and erythroid precursor cells and somatic mutations affecting the UBA1 gene. The document presents findings from a study where a patient with MDS and autoimmune disorder was identified with a UBA1 mutation, emphasizing the poor response to immunosuppressive treatments. The authors recommend screening for UBA1 mutations in similar patients to identify those likely to have VEXAS syndrome and to consider alternative therapies.
Sign in to open
Ask this resource
Answers use this document only.
Your first question is free.
More like this
Resources from the same specialty and type. Curated links will replace these when added.
Clinical Resources
Documents that extend or complement this resource.
Myeloproliferative Neoplasms
Same clinical topic · Hematology
MASTOCYTOSIS
Same clinical topic · Hematology
MYELODYSPLASTIC SYNDROMES: 2023 UPDATE ON DIAGNOSIS, RISK-STRATIFICATION, AND MANAGEMENT
Same clinical topic · Hematology
PERIPHERAL T-CELL LYMPHOMAS
Same clinical topic · Hematology
COMPARISON OF THE INTERNATIONAL CONSENSUS AND 5TH WHO EDITION CLASSIFICATIONS OF ADULT MYELODYSPLASTIC SYNDROMES AND ACUTE MYELOID LEUKEMIA
Same clinical topic · Hematology
VEXAS SYNDROME: A COMPREHENSIVE REVIEW OF PATHOGENESIS, CLINICAL SPECTRUM, AND THERAPEUTIC STRATEGIES
Same clinical topic · Hematology
IRON DEFICIENCY
Same clinical topic · Hematology
MULTIPLE MYELOMA: 2026 UPDATE ON DIAGNOSIS, RISK-STRATIFICATION AND MANAGEMENT
Same clinical topic · Hematology
ANTIDOTES FOR ANTICOAGULATION REVERSAL
Same clinical topic · Hematology