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AKI AS A SYSTEMIC SYNDROME AND ITS IMPACT ON OTHER ORGAN SYSTEMS
University Hospital Münster, Catholic University of the Sacred Heart, University of Surrey, Royal Surrey County Hospital, University of Chicago
PDF202616 pages1.4 MB
Acute kidney injury (AKI) affects approximately 15% of all hospitalized individuals and nearly half of those admitted to intensive care units. It is increasingly recognized as a systemic syndrome whose consequences extend beyond structural and functional changes confined to the kidney. Experimental studies highlight the role of inflammation and accumulation of metabolites as pivotal drivers in the cross-talk between the kidneys and distant organ systems during AKI. Clinical data reveals an association between AKI and non-renal organ dysfunctions and complications.
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