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Clinical reviews
AKI AS A SYSTEMIC SYNDROME AND ITS IMPACT ON OTHER ORGAN SYSTEMS
Department of Anaesthesiology, Intensive Care and Pain Medicine, University Hospital Münster; Department of Basic Biotechnological Sciences, Catholic University of the Sacred Heart; School of Medicine, University of Surrey; Department of Intensive Care
PDF202616 pages1.4 MB
Acute kidney injury (AKI) affects approximately 15% of all hospitalized individuals and nearly half of those admitted to intensive care units. It is increasingly recognized as a systemic syndrome whose consequences extend beyond structural and functional changes confined to the kidney. Experimental studies highlight the role of inflammation and accumulation of metabolites as pivotal drivers in the cross-talk between the kidneys and distant organ systems during AKI. This review discusses the association between AKI and non-renal organ dysfunctions and complications.
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