Beta-Blocker Use and Heart Failure Outcomes in Mildly Reduced and Preserved Ejection Fraction

Suzanne V. Arnold, Daniel N. Silverman, Kensey Gosch, Michael E. Nassif, Margaret Infeld, Sheldon Litwin, Markus Meyer, Timothy J. Fendler

This original research paper investigates the impact of beta-blocker therapy on heart failure outcomes, specifically hospitalization and death, in patients with ejection fractions of 40% or higher. Utilizing data from the U.S. PINNACLE Registry (2013-2017), the study analyzed a large cohort of outpatients aged 65 and older. The research employed propensity-score adjusted multivariable Cox regression models to assess the associations, including interactions between ejection fraction and beta-blocker use. The findings indicate a differential effect of beta-blockers based on ejection fraction levels, suggesting potential risks in HFpEF patients.