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Clinical reviews
BRAIN MINERALOCORTICOID RECEPTOR ACTIVATION AND ANTAGONISM IN HEART FAILURE WITH PRESERVED EJECTION FRACTION: A HYPOTHESIS
Karolinska Institutet, Karolinska University Hospital, University of Michigan
PDF20263 pages1.2 MB
The paper explores how aldosterone and cortisol activate central mineralocorticoid receptors, leading to various cardiovascular and cognitive impairments. It highlights the potential differences in effects between spironolactone and finerenone in managing these conditions. The authors suggest that spironolactone may offer additional benefits in reducing the risk of stroke and cognitive impairment in patients with heart failure with preserved ejection fraction.
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