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CLINDAMYCIN PLUS VANCOMYCIN VERSUS LINEZOLID FOR TREATMENT OF NECROTIZING SOFT TISSUE INFECTION
Presbyterian Hospital Department of Pharmacy, UPMC; Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine; Department of Surgery, University of Rochester Medical Center; Department of Surgery and Critical
PDF14 pages1.0 MB
Necrotizing soft tissue infections (NSTIs) are life-threatening conditions that require prompt and effective treatment. This study is a retrospective, single-center, quasi-experimental analysis comparing two antibiotic regimens for NSTI management. It aims to determine whether linezolid is a safer and more effective alternative to the combination of clindamycin and vancomycin. The findings suggest that linezolid may reduce acute kidney injury (AKI) and shorten total antibiotic exposure, leading to changes in clinical practice guidelines for NSTI treatment.
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