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Clinical reviews
COMPARATIVE EFFECTS OF GLUCOSE-LOWERING MEDICATIONS ON KIDNEY OUTCOMES IN TYPE 2 DIABETES
GRADE Research Group
PDF202310 pages1.5 MB
The GRADE trial investigates the comparative effectiveness of four classes of glucose-lowering medications added to metformin for managing glycemia in adults with type 2 diabetes. Conducted across 36 sites in the US, the trial enrolled 5047 participants with specific inclusion criteria related to diabetes duration and kidney function. The study aims to determine how these medications affect kidney function over time, addressing a critical gap in knowledge regarding diabetes management and kidney health.
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