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Carlo B Giorda, Valentina Anelli, Umberto Goglia, Stefano De Riu, Giuseppina Russo, Marco Gallo, Salvatore De Cosmo, Gerardo Corigliano, Michele Roberto Modestino
Insulin remains a cornerstone in managing advanced type 2 diabetes (T2D), but long-term use poses challenges such as hypoglycemia and weight gain. The review discusses the advent of GLP-1 receptor agonists and SGLT2 inhibitors, which enable deinsulinisation. It highlights predictors of success and emphasizes the importance of individualized approaches, particularly for older adults and those with stable glycemic control. The review aligns with ADA/EASD guidance, advocating for patient-centered care in T2D management.
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