EFFICACY OF CARBAPENEMS COMPARED WITH NONCARBAPENEM BROAD-SPECTRUM BETA-LACTAM ANTIBIOTICS AS INITIAL ANTIBIOTIC THERAPY AGAINST SEPSIS: A NATIONWIDE OBSERVATIONAL STUDY

Yutaka Umemura, MD, PhD; Kazuma Yamakawa, MD, PhD; Yoshihiro Tanaka, MD, PhD; Jumpei Yoshimura, MD; Hiroshi Ogura, MD, PhD; Satoshi Fujimi, MD, PhD

The research investigates the survival effects associated with carbapenem therapy in patients diagnosed with sepsis compared to alternative empiric regimens. It utilizes data from a large-scale database in Japan, analyzing in-hospital mortality rates among patients treated with either carbapenems or noncarbapenem antibiotics. The study aims to provide insights into the effectiveness of these antibiotic classes in managing sepsis, particularly in light of the need to reduce the indiscriminate use of carbapenems.