FROM ADIPOSITY TO MULTISYSTEM MORBIDITY: THE CASE FOR WEIGHT LOSS AS DISEASE MODIFICATION

School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK

Obesity is a significant contributor to a range of health issues, including musculoskeletal, metabolic, cardiovascular, mental health, respiratory, and gastrointestinal disorders. The review assesses the causal links between adiposity and these diseases through a comprehensive analysis of epidemiological studies, genetic analyses, and randomized trials. It emphasizes the effectiveness of weight loss as a disease-modifying strategy for certain conditions, while also identifying gaps in research for others. The authors advocate for future trials to explore the benefits of weight management across various disease stages and mechanisms.