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Clinical reviews
FUNGAL DIMORPHISM AND VIRULENCE: MOLECULAR MECHANISMS FOR TEMPERATURE ADAPTATION, IMMUNE EVASION, AND IN VIVO SURVIVAL
University of Wisconsin School of Medicine & Public Health
PDF20178 pages656 KB
The thermally dimorphic fungi are a unique group within the Ascomycota phylum that can convert between hyphae and yeast forms depending on temperature. This morphologic switch is essential for their survival and virulence in mammalian hosts, particularly in evading immune responses. The review delves into recent advances in understanding the molecular mechanisms that govern this transition and how it enhances the fungi's ability to cause disease.
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