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Marcella Donovan Walker, MD; Elizabeth Shane, MD
Hypercalcemia affects approximately 1% of the global population and can range from mild, often asymptomatic cases to severe, life-threatening conditions. The review highlights that primary hyperparathyroidism and malignancy are the most common causes of hypercalcemia. It also details the clinical manifestations, diagnostic approaches, and treatment strategies, including hydration and pharmacological interventions. The importance of distinguishing between PTH-dependent and PTH-independent causes is underscored, along with the need for tailored treatment based on the underlying etiology.
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