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The document provides a comprehensive review of the evidence linking magnesium deficiency to hypertension, highlighting both systemic and renal mechanisms. It examines how magnesium influences vascular smooth muscle cells, the renin-angiotensin-aldosterone system, and various hormonal regulators of magnesium transport in the kidneys. The review also addresses the implications of magnesium levels in the context of salt-sensitive hypertension and genetic factors affecting magnesium metabolism.
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