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Metabolic Diseases Research Unit, IRCCS Sacro Cuore Don Calabria Hospital
This review discusses the global clinical burden and consequences of MASLD as a multisystem disease, briefly describing the natural history, pathophysiology, risk stratification, and case finding of the disease. It focuses on the new and promising metabolism-based pharmacotherapies targeting the liver and coexisting cardiovascular–kidney–metabolic conditions of MASLD.
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