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Mayo Clinic, Rochester, MN, USA
Opioid-induced adrenal insufficiency (OIAI) is increasingly recognized as a significant clinical issue among patients on chronic opioid therapy. The review discusses the pathophysiology of OIAI, the diagnostic challenges, and the importance of differential diagnosis. It emphasizes the need for heightened awareness among clinicians to facilitate early detection and appropriate management, which may include discontinuation of opioids and glucocorticoid therapy if necessary.
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