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Clinical reviews
VENTRICULAR AFTERLOAD, PRELOAD, AND CARDIAC FUNCTION
Sheldon Magder, Douglas Slobod, Marco Leali
PDF6 pages907 KB
The authors argue that the traditional definitions of preload and afterload, derived from studies on amphibian skeletal muscles, do not apply to cardiac muscle. They propose that cardiac force production is governed by a time-varying elastance of the heart walls, leading to a new understanding of how the heart functions during systole. The document emphasizes the importance of end-diastolic volume and introduces the term 'threshold load' to describe the pressure needed to open the ventricular outflow valves, which is crucial for understanding cardiac output dynamics.
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