APPRAISING THE PRECLINICAL EVIDENCE OF THE ROLE OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN ANTENATAL PROGRAMMING OF MATERNAL AND OFFSPRING CARDIOVASCULAR HEALTH ACROSS THE LIFE COURSE: MOVING THE FIELD FORWARD: A SCIENTIFIC STATEMENT FROM THE

American Heart Association

The statement highlights emerging antenatal risk factors such as preeclampsia that increase the risk of hypertension and cardiovascular disease across the life course for both mothers and their offspring. It emphasizes the complexity of antenatal programming mechanisms and the critical role of the renin-angiotensin-aldosterone system in regulating maternal-fetal health. The document aims to advance understanding of these mechanisms to improve maternal and offspring cardiovascular health outcomes.