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The CMR GUIDE Randomized Clinical Trial enrolled adults with ischemic or nonischemic cardiomyopathy and an LVEF of 36% to 50% who were receiving guideline-directed medical therapy. The trial aimed to assess the effectiveness of ICDs compared to implantable loop recorders in preventing sudden cardiac death and significant ventricular arrhythmias. The study highlights the importance of myocardial scar assessment using cardiovascular magnetic resonance imaging in guiding ICD implantation decisions.
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