EFFICACY AND SAFETY OF MINOCYCLINE IN PATIENTS WITH ACUTE ISCHAEMIC STROKE (EMPHASIS): A MULTICENTRE, DOUBLE-BLIND, RANDOMISED CONTROLLED TRIAL

Yao Lu, Ling Guan, Jialing Wu, Qianqian Yang, Meiyang Zhang, Dongyang Zhou, Hongqin Yang, Yuesong Pan, Luyan Wang, Baoshan Qiu, Chenhui Liu, Yicong Wang, Yingying Yang, Xuejiao Zhou, Hui Qu, Xiaoling Liao, Liping Liu, Xingquan Zhao, Philip M Bath, S

Minocycline has been identified as a multi-target anti-neuroinflammatory drug with potential benefits for ischaemic stroke based on preclinical models and smaller clinical studies. This trial was conducted across 58 hospitals in China, enrolling patients who experienced an ischaemic stroke within the previous 72 hours. Participants were randomly assigned to receive either minocycline or a placebo in addition to routine treatment, aiming to evaluate the drug's impact on recovery outcomes.