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Clinical reviews
EFFICACY AND SAFETY OF PRASUGREL COMPARED WITH CLOPIDOGREL IN PATIENTS WITH ACUTE CORONARY SYNDROMES: RESULTS OF TRITON-TIMI 38 TRIALS
Dipartimento Cardiovascolare, Ospedale Civile di Legnano, Milan, Italy
PDF20097 pages305 KB
The TRITON-TIMI 38 trial randomized 13,608 moderate-to-high-risk patients with acute coronary syndromes to compare the effects of prasugrel and clopidogrel. The study found that prasugrel significantly reduced ischemic events compared to clopidogrel; however, this benefit was accompanied by a notable increase in major bleeding incidents. The findings suggest that while prasugrel may offer improved outcomes for certain patients, careful consideration of bleeding risks is essential.
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