GUILLAIN–BARRÉ SYNDROME

Sonja E. Leonhard, Nowshin Papri, Luis Querol, Simon Rinaldi, Nortina Shahrizaila, Bart C. Jacobs

This primer provides a comprehensive overview of Guillain–Barré syndrome, detailing its epidemiology, mechanisms, diagnosis, and management strategies. It highlights the immune response triggered by infections, particularly Campylobacter jejuni, and the resulting damage to peripheral nerves. The document also addresses the effectiveness of treatments such as plasma exchange and intravenous immunoglobulins, while noting the significant proportion of patients who experience persistent deficits. Furthermore, it emphasizes the need for further research into the pathogenesis and treatment of GBS, especially in low-income settings.