INCLUSION BODY MYOSITIS: CLINICAL FEATURES AND PATHOGENESIS

Steven A. Greenberg

Inclusion body myositis (IBM) is a slowly progressive skeletal muscle disease characterized by unique clinical features such as finger flexor and quadriceps weakness, along with pathological features including the presence of infiltrating cytotoxic T cells in muscle. Recent findings suggest that IBM may be an autoimmune T cell-mediated disease, challenging previous notions of its treatment refractoriness. Advances in biomarker identification and genetic studies have provided new insights into the disease's pathogenesis and potential therapeutic avenues.