PRACTICAL “1-2-3-4-DAY” RULE FOR STARTING DIRECT ORAL ANTICOAGULANTS AFTER ISCHEMIC STROKE WITH ATRIAL FIBRILLATION: COMBINED HOSPITAL-BASED COHORT STUDY

Shunsuke Kimura, MD; Kazunori Toyoda, MD; Sohei Yoshimura, MD; Kazuo Minematsu, MD; Masahiro Yasaka, MD; Maurizio Paciaroni, MD; David J. Werring, MD; Hiroshi Yamagami, MD; Takehiko Nagao, MD; Shinichi Yoshimura, MD; Alexandros Polymeris, MD; Annaelle

The research utilizes combined data from multiple prospective registries in Japan to assess the timing of DOAC initiation after ischemic events. It categorizes patients based on the severity of their strokes and evaluates outcomes related to recurrent strokes and bleeding incidents. The findings suggest that earlier initiation of DOACs may reduce the risk of recurrent embolic events, challenging existing guidelines that recommend longer waiting periods.