RESISTANT HYPERTENSION: EPIDEMIOLOGY, MECHANISMS AND CONTEMPORARY THERAPEUTIC STRATEGIES

Department of Cardiology, ESIC Medical College and Hospital, Faridabad, Haryana, India; Department of Cardiology, AIIMS Bhopal, Bhopal, Madhya Pradesh, India; Department of Medicine, MGM Medical College, Indore, Madhya Pradesh, India

Resistant hypertension (RH) is defined as uncontrolled blood pressure on three or more antihypertensive agents or controlled blood pressure on four or more. It is associated with significant cardiovascular risks, including stroke and heart failure. The document highlights the importance of accurate diagnosis, distinguishing true RH from pseudo-resistance, and emphasizes a comprehensive management approach that includes lifestyle modifications and potential device-based therapies. The authors synthesize current knowledge on RH's mechanisms and therapeutic strategies.