SHORT-TERM ANTICOAGULANT THERAPY AND SUBCLINICAL LEAFLET THICKENING IN TRANSCATHETER AORTIC VALVES

Troels Højsgaard Jørgensen, MD, PhD; Andreas Fuchs Larsen, MD, PhD; Jesper Møller Jensen, MD, PhD; Rebekka Vibjerg Jensen, MD, PhD; Yannick Willemen, MD, PhD; Aekapat Phoksiri, MD; Arif Khokhar, BMBCH, MA; Jani Thuraiaiyah, MD, PhD; Kamilla Bech

The NOTION-4 trial was a randomized controlled trial aimed at evaluating the prevalence of hypoattenuated leaflet thickening (HALT) in patients undergoing TAVR. Patients were assigned to either single antiplatelet therapy (SAPT) or a regimen of direct oral anticoagulant (DOAC) therapy followed by SAPT. The study's primary endpoint was the prevalence of HALT at 12 months, with findings indicating a significant difference in HALT rates between the two treatment groups.