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The study aimed to determine whether vitamin E supplementation could reduce the risks of major cardiovascular events and cancer in a cohort of 39,876 apparently healthy women aged 45 and older. Participants were randomly assigned to receive either vitamin E or a placebo, with follow-up over an average of 10.1 years. The results indicated a nonsignificant reduction in cardiovascular events among those taking vitamin E, contrasting with previous observational studies suggesting potential benefits.
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