WITHDRAWAL OF PHARMACOLOGICAL TREATMENT FOR HEART FAILURE IN PATIENTS WITH RECOVERED DILATED CARDIOMYOPATHY (TRED-HF): AN OPEN-LABEL, PILOT, RANDOMISED TRIAL

Royal Brompton and Harefield NHS Foundation Trust, London, UK

The study investigates whether patients with dilated cardiomyopathy, who have shown recovery in symptoms and cardiac function, can safely discontinue their heart failure medications. It focuses on patients whose left ventricular ejection fraction has improved and who are asymptomatic. The trial was conducted in the UK, with patients randomly assigned to either a phased withdrawal of treatment or continuation of their medication, assessing the primary endpoint of relapse in heart failure symptoms over a six-month period.